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Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

Lee JH, Leaman DP, Kim AS, Torrents de la Pena A, Sliepen K, Yasmeen A, Derking R, Ramos A, de Taeye SW, Ozorowski G, Klein F, Burton DR, Nussenzweig MC, Poignard P, Moore JP, Klasse PJ, Sanders RW, Zwick MB, Wilson IA, Ward AB

NAT.COMMUN. 6 8167-8173 (2015) PMID: 26404402

EMDB › EMD-3067

http://www.ebi.ac.uk/pdbe/entry/emdb/EMD-3067/

Single particle reconstruction

9.3Å resolution

cryoEM reconstruction of 3BC315 Fab in complex with BG505 SOSIP.664 Env trimer

Map released: 2015-10-07

Overview of EMD-3067

Source organisms:

Human Immunodeficiency Virus-1 [null]

Homo sapiens [9606]

Primary publication:

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

Lee JH, Leaman DP, Kim AS, Torrents de la Pena A, Sliepen K, Yasmeen A, Derking R, Ramos A, de Taeye SW, Ozorowski G, Klein F, Burton DR, Nussenzweig MC, Poignard P, Moore JP, Klasse PJ, Sanders RW, Zwick MB, Wilson IA, Ward AB

NAT.COMMUN. 6 8167-8173 (2015) PMID: 26404402