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How insulin engages its primary binding site on the insulin receptor

Menting, J.G., Whittaker, J., Margetts, M.B., Whittaker, L.J., Kong, G.K.-W., Smith, B.J., Watson, C.J., Zakova, L., Kletvikova, E., Jiracek, J., Chan, S.J., Steiner, D.F., Dodson, G.G., Brzozowski, A.M., Weiss, M.A., Ward, C.W., Lawrence, M.C.

Nature 493: 241-245 (2013)

PDB ID: 3W14

http://www.rcsb.org/pdb/explore/explore.do?structureId=3w14

Insulin receptor ectodomain construct comprising domains L1,CR,L2, FNIII-1 and alphact peptide in complex with bovine insulin and FAB 83-14

Deposited: 2012-11-06 Released: 2013-01-09

Deposition author(s): Lawrence, M.C., Smith, B.J. Organism: Bos taurus | Mus musculus | Homo sapiens Expression System: Mus musculus, Cricetulus griseus, Mus musculus

Method: X-RAY DIFFRACTION

Resolution: 4.4 Å

R-Value Free: 0.262

R-Value Work: 0.245

Primary Citation

How insulin engages its primary binding site on the insulin receptor

Menting, J.G., Whittaker, J., Margetts, M.B., Whittaker, L.J., Kong, G.K.-W., Smith, B.J., Watson, C.J., Zakova, L., Kletvikova, E., Jiracek, J., Chan, S.J., Steiner, D.F., Dodson, G.G., Brzozowski, A.M., Weiss, M.A., Ward, C.W., Lawrence, M.C.

Nature 493: 241-245 (2013)