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Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.

Schweizer, U., Schlicker, C., Braun, D., Kohrle, J., Steegborn, C.

Proc.Natl.Acad.Sci.USA 111: 10526 (2014)

PDB ID: 4TR3

http://www.rcsb.org/pdb/explore/explore.do?structureId=4TR3

Mouse iodothyronine deiodinase 3 catalytic core, SeMet-labeled active site mutant SeCys->Cys

DOI: 10.2210/pdb4tr3/pdb

Classification: OXIDOREDUCTASE

Deposited: 2014-06-13 Released: 2014-07-23

Deposition author(s): Steegborn, C., Schweizer, U., Schlicker, C.

Organism: Mus musculus

Expression System: Escherichia coli

Mutation(s): 1

Structural Biology Knowledgebase: 4TR3 (>18 annotations) SBKB.org

Experimental Data Snapshot

Method: X-RAY DIFFRACTION

Resolution: 1.9 Å

R-Value Free: 0.227

R-Value Work: 0.187

wwPDB Validation Full Report

Primary Citation

Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism.

Schweizer, U., Schlicker, C., Braun, D., Kohrle, J., Steegborn, C.

Proc.Natl.Acad.Sci.USA 111: 10526 (2014)

PubMed: 25002520 Search on PubMed PubMedCentral: PMC4115520 DOI: 10.1073/pnas.1323873111